Figure 2 | Scientific Reports

Figure 2

From: MDMX elevation by a novel Mdmx–p53 interaction inhibitor mitigates neuronal damage after ischemic stroke

Figure 2

K-181 increased Mdmx expression in mice brain under physiological condition. (A,B) Relative inhibition activity on Mdmx–p53 (A) and Mdm2–p53 (B) interaction using chemical compounds at 12.5 μM. N = 3. (C) Mice were orally administrated with K-181, K-178, K-564 and vehicles at 50 mg/kg/day for consecutive 14 days. (D–H) Western blot (D) and quantification of Mdmx (E), Mdm2 (F), p53 (G) and E2F1 (H) in mice brains. N = 4.

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