Figure 6 | Scientific Reports

Figure 6

From: MDMX elevation by a novel Mdmx–p53 interaction inhibitor mitigates neuronal damage after ischemic stroke

Figure 6

K-181 selectively inhibits HDAC6 activity and enhances Tubulin acetylation. (A,B) HDAC6 inhibition assay of 0.1, 0.3, 1, 3, 10, 30, 100 μM K-181 (A) and K-181SH (B). N = 3. (C–K) Western Blot images (C) and quantification of HDAC1 (D), HDAC2 (E), HDAC3 (F), HDAC4 (G), HDAC5 (H), HDAC6 (I), HDAC7 (J) and HDAC9 (K) expression in vehicle and K-181 treated mice brains. N = 6. (L,M) Western Blot images (L) and quantification (M) of Tubulin3 (acetyl K40) in vehicle and K-181 treated mice brains. N = 6.

Back to article page