Table 1 HDAC1, HDAC4 and HDAC6 inhibition assay of K-178, K-178SH, K-181, K-181SH, Tubacin and Trichostatin A.
Compound tested | HDAC1 activity assay | HDAC4 activity assay | HDAC6 activity assay | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Inhibition (%) | Average of Inhibition (%) | Inhibitory activity* | Inhibition (%) | Average of Inhibition (%) | Inhibitory activity* | Inhibition (%) | Average of Inhibition (%) | Inhibitory activity* | ||||
K-178 | 17.75 | 7.93 | 12.84 | N/A | 13.19 | 6.95 | 10.07 | N/A | 39.74 | 30.59 | 35.16 | N/A |
K-178SH | 5.56 | 12.23 | 8.9 | N/A | 9.89 | 8.1 | 8.99 | N/A | 41.16 | 35.49 | 38.32 | N/A |
K-181 | 16.76 | 17.1 | 16.93 | N/A | 12.22 | 12.22 | 12.22 | N/A | 55.51 | 59.12 | 57.32 | Yes |
K-181SH | 21.58 | 24.73 | 23.15 | N/A | 14.38 | 16.3 | 15.34 | N/A | 68.85 | 70.78 | 69.81 | Yes |
Tubacin | 97.65 | 97.22 | 97.43 | Yes | 87.71 | 87.27 | 87.49 | Yes | 100 | 100 | 100 | Yes |
Trichostatin A | 99.94 | 99.61 | 99.78 | Yes | 97.7 | 97.51 | 97.61 | Yes | 99.37 | 99.54 | 99.45 | Yes |
