Figure 7
From: Tranilast protects pancreatic β-cells from palmitic acid-induced lipotoxicity via FoxO-1 inhibition
Acute in vivo effect of tranilast was studied using C57BL/6J mice. Male C57BL/6J mice (6-weeks old) were orally administered either vehicle (0.5% CMC) or tranilast (50 and 100 mg/kg, n = 8 per group) at three time points (9 AM, 7 PM, and 9 AM on the 2nd day). (A,C) Fasting glucose and insulin levels were determined after overnight fasting, and glucose tolerance test was carried out (B). (D) mRNA levels of PDX-1, insulin, and FoxO-1 in whole pancreas were measured by real-time qPCR. *p < 0.05, **p < 0.01, ***p < 0.005 versus vehicle group.
