Table 1 Comparison of AP data measured by whole cell and perforated patch clamp configurations.

From: The reverse mode of the Na+/Ca2+ exchanger contributes to the pacemaker mechanism in rabbit sinus node cells

Applied configuration

Whole cell

Perforated patch

2 mM [Na+]pip

8 mM [Na+]pip

2 mM [Na+]pip

8 mM [Na+]pip

Cycle length (ms)

463 ± 38

369 ± 15*

478 ± 31

392 ± 25*

APD (ms)

232 ± 11

189 ± 3*

226 ± 17

179 ± 11*

Diastolic slope (mV/ms)

0.07 ± 0.01

0.12 ± 0.02*

0.05 ± 0.01

0.098 ± 0.01*

MDP (mV)

− 49 ± 2

− 55 ± 3

− 52 ± 3

− 53 ± 4

  1. *Indicate significant (p < 0.05) differences between [Na]pip groups within the same configuration.
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