Figure 1 | Scientific Reports

Figure 1

From: Bisphosphonate affects the behavioral responses to HCl by disrupting farnesyl diphosphate synthase in mouse taste bud and tongue epithelial cells

Figure 1

Farnesyl diphosphate synthase (FDPS) mRNA was expressed in mouse taste buds. Reverse transcription-polymerase chain reaction was used to amplify the mRNAs for mevalonate pathway component molecules from the circumvallate papillae (CV), fungiform papillae (FP), tongue non-taste epithelial tissue, and liver (positive control for mevalonate pathway components) of B6 mice. Mevalonate pathway components: FDFT squalene synthase, GGPS geranylgeranyl diphosphate synthase, HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase, Mvd mevalonate pyrophosphate decarboxylase, Mvk mevalonate kinase, Pmvk phosphomevalonate kinase. Gustducin (a taste cell marker); Gapdh glyceraldehyde-3-phosphate dehydrogenase (housekeeping gene), M (bp) 100 bp marker ladder. Uncropped blots can be found in Supplementary Fig. S5.

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