Figure 2 | Scientific Reports

Figure 2

From: Bisphosphonate affects the behavioral responses to HCl by disrupting farnesyl diphosphate synthase in mouse taste bud and tongue epithelial cells

Figure 2

FDPS immunoreactivity (green) in the circumvallate papillae (CV) and the fungiform papillae (FP) of mice was observed mainly in taste bud type III cells. (A) Many FDPS-positive cells were also carbonic anhydrase-4 (CA4)-positive (magenta). Arrowheads denote FDPS + CA4 double-positive cells. (B,C) A few FDPS-positive cells also expressed taste receptor type 1 member 3 (T1R3, red) or gustducin (cyan). Dotted lines outline individual taste buds. Scale bars: 25 μm. (D,E) Summary of the pattern of co-expression between FDPS and taste cell markers in CV (D) and FP (E) taste cells. The area of each ellipse indicates the number of taste bud cells expressing FDPS, T1R3, gustducin or CA4 in the each taste papillae of the mouse. Regions of overlap indicate co-expression. This diagram is based on Table 1.

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