Figure 4 | Scientific Reports

Figure 4

From: Bisphosphonate affects the behavioral responses to HCl by disrupting farnesyl diphosphate synthase in mouse taste bud and tongue epithelial cells

Figure 4

Risedronate enhanced the behavioral responses to HCl in mice. Lick ratios for varying concentrations of HCl (A), NaCl (B), KCl (C), sucrose combined with 0.5 mM quinine-HCl (Suc + 0.5 Q) (D), quinine-HCl (QHCl) (E) and monopotassium glutamate combined with 0.5 mM quinine-HCl (MPG + 0.5 Q) (F). The data were obtained after the intraperitoneal administration of vehicle (Ctrl, white symbols) or 15 mg/kg body weight risedronate (Rise, blue symbols) three times per week for 28 days. The lick ratio to distilled water is presented as the mean ± SEM (n = 9–21 mice). *P < 0.05, **P < 0.01, ***P < 0.001 (two-way ANOVA and post-hoc Student's t-test; see Table 4).

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