Figure 5

Risedronate did not affect the chorda tympani (CT) nerve and the glossopharyngeal (GL) nerve response to basic taste stimuli in mice. CT nerve (A) and GL nerve (B) responses to sour (3 mM HCl), salty (100 mM NaCl), sweet (300 mM sucrose [Suc]), umami (100 mM monopotassium glutamate [MPG]) and bitter (10 mM quinine-HCl [QHCl]) compounds were recorded after the administration of vehicle (Ctrl, white bars) or 15 mg/kg body weight risedronate (Rise, blue bars) three times per week for 28 days. Gustatory nerve responses were normalized to the response to 100 mM NH₄Cl. Data are presented as the mean ± SEM (n = 3–5 mice). P > 0.05 (Student's t-test, see Table 5).