Table 1 Pharmacodynamic parameter estimates. Population, random between experiment variability (BSV), precision (%RSE) and Shrinkage estimates.
From: Emergence of phenotypic and genotypic antimicrobial resistance in Mycobacterium tuberculosis
Parameter | Population estimate (95% CI) | %RSE | BSV(CV%) | Shrinkage (SD)% |
|---|---|---|---|---|
knet | 0.368 (0.346, 0.391) | 3.14 | 15.5 | 5.84% |
bmax | 86.6 (76.7, 97.7) | 1.39 | 32.6 | 2.06% |
B0 | 134 (112, 160) | 1.86 | 47.7 | 5.43% |
EMAX-INH | 0.734 (0.724, 0.745) | 2.35 | 2.34 | 87.10% |
RIF interaction at re-exposure effect | − 0.568 (− 0.646, − 0.491) | 6.96 | ||
IC50-INH | 783 (721, 851) | 0.635 | 13.1 | 87.20% |
Re-exposure effect | 4.02 (3.8, 4.24) | 2.79 | ||
HIllINH | 0.756 (0.634, 0.901) | 32.1 | 15.9 | 85.70% |
λINH | 0.212 (0.21, 0.214) | 0.359 | ||
Re-exposure effect | − 0.169 (− 0.169, − 0.168) | 0.194 | ||
RIF interaction effect | − 0.32 (− 0.321, − 0.318) | 0.218 | ||
EMAX-RIF | 0.43 (0.43, 0.43) | 0.047 | 44 | 45.90% |
INH interaction at re-exposure effect | 0.421 (0.403, 0.438) | 2.12 | ||
IC50-RIF | 46.8 (46.7, 46.8) | 0.0138 | 32.1 | 84.80% |
Re-exposure effect | 1.82 (1.81, 1.83) | 0.352 | ||
λRIF | 0.153 (0.153, 0.153) | 0.0214 | ||
INH interaction effect | 0.582 (0.58, 0.584) | 0.18 | ||
Residual variability (proportional) | 0.232 |
