Figure 2 | Scientific Reports

Figure 2

From: Design, synthesis, in vitro, in silico, and SAR studies of flavone analogs towards anti-dengue activity

Figure 2

(A) Preparation of flavone analogs via semi-synthessis approach and (B) preparation of flavone analogs via total synthesis approach; aalkyl halide (1.5–5.0 equiv.), K2CO3 (2.0–5.0 equiv.), acetone or DMF, 60–100 °C; bacyl anhydride (30 equiv.), pyridine, rt; cHNO3 (1.0–2.25 equiv.), AcOH, 60 °C; dNBS (1.1–4.0 equiv.), THF, rt–60 °C; eSn (5.0–10.0 equiv.) 12 M HCl, EtOH; fBBr3 (3.0 equiv), CH2Cl2, gAlCl3 (5.0 equiv), toluene, reflux; h47% HBr, AcOH, reflux.

Back to article page