Figure 4
From: Transcriptomic and proteomic pathways of diabetic and non-diabetic mitochondrial transplantation
Myocardial function and viability. Left ventricular fractional shortening (A), determined by echocardiography in Vehicle hearts and in hearts receiving diabetic ZDF- or non-diabetic ZL-mitochondria at day 0 (baseline) and at 1, 7,14, 21 and 28 days recovery. Representative M mode at 28 days recovery is provided (B). Area at risk as percentage of left ventricular mass in Vehicle hearts and in hearts receiving diabetic ZDF- or non-diabetic ZL -mitochondria following 30 min regional ischemia at 2 h (C) and 28 days recovery (D). Infarct size as % of area at risk in Vehicle hearts and in hearts receiving diabetic ZDF- or non-diabetic ZL -mitochondria following 30 min regional ischemia at 2 h (E) and 28 days recovery (F). Representative images of ZDF rat hearts stained with 1% triphenyltetrazolium chloride (TTC) for hearts receiving vehicle alone, diabetic ZDF- or non-diabetic ZL -mitochondria, following 30 min regional ischemia and at 2 h and 28 days recovery (G). White areas show myocardial necrosis. Brick red areas show viable tissue. Scale in cm is shown. All results are shown as the mean plus and minus the standard error of the mean for n = 6 for each group. Statistical differences are shown as * p < 0.05, ** p < 0.01, ***p < 0.001; ns: not significant.
