Figure 7
From: Transcriptomic and proteomic pathways of diabetic and non-diabetic mitochondrial transplantation
Transcriptomic pathways following 30 min of regional myocardial ischemia and 28 days recovery. (A) Principal component analysis (PCA) for hearts receiving diabetic ZDF- (gold circles) or non-diabetic ZL -mitochondrial transplantation (blue circles) as compared to hearts receiving vehicle alone. (B) Heatmap of transcriptional regulation patterns following 30 min of IRI and 28 days recovery for hearts receiving diabetic ZDF- (gold circles) or non-diabetic ZL -mitochondrial transplantation (blue circles). Fold changes (FC) are derived from comparison to Vehicle hearts. The log FC of gene expression is shown with pseudocolor scale (− 1 to 2), with blue denoting downregulation and orange denoting upregulation. Columns represent FC comparisons, and rows represent the genes. Experimental groups are found on the bottom. (C) Gene set enrichment analysis for hearts receiving diabetic ZDF- or non-diabetic ZL -mitochondrial transplantation. Pathways of interest are shown in red and indicated by arrows.
