Figure 4 | Scientific Reports

Figure 4

From: Filaggrin and cytokines in respiratory samples of preterm infants at risk for respiratory viral infection

Figure 4

Filaggrin is altered in SAEC by viral stimuli and wounds in the monolayer. (a) Gene expression of FLG (n = 6–8), TLR3 (n = 6–8), TSLP (n = 7–9), AREG (n = 7–9), CAPN14 and DSG1 (n = 6–9) (relative expression as 2−∆∆Ct) measured by qPCR and (b) filaggrin (pg/mL) protein synthesis measured by ELISA in SAEC treated with 20 ng/mL of poly:IC (polyinosinic:polycytidylic acid), wounded, or treated with poly:IC and wounded for 24 h (n = 5–9). Inter-group analysis was performed using the Kruskal–Wallis test with multiple comparisons test followed by Dunn’s post-test. Bar graphs represent median and interquartile ranges. SAEC small airway epithelial cells. *P < 0.05; **P < 0.01.

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