Table 2 Hallmark gene sets analysis in mouse gastrocnemius between young sham (YS), young burn (YB), adult sham (AS), and adult burn (AB) groups.

From: Skeletal muscle transcriptome is affected by age in severely burned mice

Order	Age effect (YS vs. AS)		Burn in adults (AB vs. AS)		Burn in youngs (YB vs. YS)		Burn with age (YB vs. AB)
Order	Pathway	N	Pathway	N	Pathway	N	Pathway	N
#01	MYOGENESIS	64	MTORC1_SIGNALING	17	COMPLEMENT	10	MYOGENESIS	74
#02	EPITHELIAL_MESENCHYMAL_TRANSITION	46	MYC_TARGETS_V1	15	KRAS_SIGNALING_UP	10	EPITHELIAL_MESENCHYMAL_TRANSITION	63
#03	ADIPOGENESIS	37	MYOGENESIS	15	EPITHELIAL_MESENCHYMAL_TRANSITION	9	UV_RESPONSE_DN	39
#04	MTORC1_SIGNALING	36	ADIPOGENESIS	12	MTORC1_SIGNALING	9	MYC_TARGETS_V1	45
#05	HYPOXIA	30	REACTIVE_OXYGEN_SPECIES_PATHWAY	6	MYOGENESIS	9	MTORC1_SIGNALING	44
#06	UV_RESPONSE_DN	24	KRAS_SIGNALING_UP	8	COAGULATION	7	ADIPOGENESIS	40
#07	OXIDATIVE_PHOSPHORYLATION	28	P53_PATHWAY	7	APOPTOSIS	7	APICAL_JUNCTION	37
#08	FATTY_ACID_METABOLISM	23	ESTROGEN_RESPONSE_EARLY	6	ADIPOGENESIS	7	HYPOXIA	37
#09	GLYCOLYSIS	25	ESTROGEN_RESPONSE_LATE	6	GLYCOLYSIS	7	UNFOLDED_PROTEIN_RESPONSE	27
#10	APICAL_JUNCTION	23	UV_RESPONSE_UP	5	INTERFERON_GAMMA_RESPONSE	7	COMPLEMENT	36
#11	P53_PATHWAY	23	APOPTOSIS	5	MYC_TARGETS_V1	7	ESTROGEN_RESPONSE_LATE	35
#12	MITOTIC_SPINDLE	22	ANDROGEN_RESPONSE	4	UV_RESPONSE_UP	6	INTERFERON_ALPHA_RESPONSE	24
#13	ESTROGEN_RESPONSE_EARLY	21	BILE_ACID_METABOLISM	4	HYPOXIA	6	MITOTIC_SPINDLE	34
#14	HEME_METABOLISM	21	GLYCOLYSIS [200]	5	ALLOGRAFT_REJECTION	5	KRAS_SIGNALING_UP	34
#15	UNFOLDED_PROTEIN_RESPONSE	15	OXIDATIVE_PHOSPHORYLATION	5	APICAL_JUNCTION	5	P53_PATHWAY	34
#16	TNFA_SIGNALING_VIA_NFKB	20	PEROXISOME	3	TNFA_SIGNALING_VIA_NFKB	5	ESTROGEN_RESPONSE_EARLY	33
#17	UV_RESPONSE_UP	17	HYPOXIA	4	FATTY_ACID_METABOLISM	4	TNFA_SIGNALING_VIA_NFKB	33
#18	G2M_CHECKPOINT	19	INTERFERON_GAMMA_RESPONSE	4	INTERFERON_ALPHA_RESPONSE	3	GLYCOLYSIS	32
#19	XENOBIOTIC_METABOLISM	19	TNFA_SIGNALING_VIA_NFKB	4	INFLAMMATORY_RESPONSE	4	HEME_METABOLISM	32
#20	APOPTOSIS	15	XENOBIOTIC_METABOLISM	4	P53_PATHWAY	4	INTERFERON_GAMMA_RESPONSE	32
#21	MYC_TARGETS_V1	17	UNFOLDED_PROTEIN_RESPONSE	3			ANDROGEN_RESPONSE	22
#22	REACTIVE_OXYGEN_SPECIES_PATHWWAY	8					UV_RESPONSE_UP	28
#23	ANDROGEN_RESPONSE	11					APOPTOSIS	28
#24	IL2_STAT5_SIGNALING	16					MYC_TARGETS_V2	16
#25	PEROXISOME [104]	11					IL2_STAT5_SIGNALING	30
#26	ESTROGEN_RESPONSE_LATE	16					G2M_CHECKPOINT	30
#27	PI3K_AKT_MTOR_SIGNALING	11					XENOBIOTIC_METABOLISM	30
#28	MYC_TARGETS_V2	8					COAGULATION	24
#29	BILE_ACID_METABOLISM	11					OXIDATIVE_PHOSPHORYLATION	29
#30	KRAS_SIGNALING_UP	15					FATTY_ACID_METABOLISM	25
#31	TGF_BETA_SIGNALING	7					E2F_TARGETS	27
#32	PROTEIN_SECRETION	9					INFLAMMATORY_RESPONSE	27
#33	COMPLEMENT	13					TGF_BETA_SIGNALING	13
#34	KRAS_SIGNALING_DN	13					CHOLESTEROL_HOMEOSTASIS	15
#35	COAGULATION	10					PROTEIN_SECRETION	17
#36	NOTCH_SIGNALING	4					BILE_ACID_METABOLISM	18
#37	CHOLESTEROL_HOMEOSTASIS	6					PI3K_AKT_MTOR_SIGNALING	17
#38	ANGIOGENESIS	4					PEROXISOME	16
#39							REACTIVE_OXYGEN_SPECIES_PATHWAY	10
#40							ANGIOGENESIS	8
#41							ALLOGRAFT_REJECTION	21
#42							DNA_REPAIR	17
#43							IL6_JAK_STAT3_SIGNALING	11
#44							APICAL_SURFACE	7
#45							HEDGEHOG_SIGNALING	6

Hallmark gene sets summarize 50 specific well-defined biological processes, which were generated by a computational methodology based on identifying overlaps between gene sets in other MSigDB collections and retaining genes that display coordinate expression.
N, The number of altered genes.

Back to article page

Table 2 Hallmark gene sets analysis in mouse gastrocnemius between young sham (YS), young burn (YB), adult sham (AS), and adult burn (AB) groups.

Search

Quick links