Table 3 Wiki gene sets analysis in mouse gastrocnemius between young sham (YS), young burn (YB), adult sham (AS), and adult burn (AB) groups. N: the number of altered genes.

From: Skeletal muscle transcriptome is affected by age in severely burned mice

Order

Age effect (YS vs. AS)

Burn in adults (AB vs. AS)

Burn in youngs (YB vs. YS)

Burn with age (YB vs. AB)

Pathway

N

Pathway

N

Pathway

N

Pathway

N

#01

VEGFAVEGFR2_SIGNALING

64

PROTEASOME_DEGRADATION

26

PROTEASOME_DEGRADATION

10

VEGFAVEGFR2_SIGNALING

89

#02

FOCAL_ADHESIONPI3KAKTMTOR

38

PARKINUBIQUITIN_PROTEASOMAL_SYSTEM

18

PARKINUBIQUITIN_PROTEASOMAL_SYSTEM

6

FOCAL_ADHESION_PI3K_AKT_MTOR

58

#03

FOCAL_ADHESION

28

NUCLEAR_RECEPTORS_METAPATHWAY

12

MICROGLIA_PATHOGEN_PHAGOCYTOSIS

5

MYOMETRIAL_RELAXATION_AND_CONTRACTION

40

#04

ADIPOGENESIS

22

SELENIUM_MICRONUTRIENT_NETWORK

6

COMPLEMENT_AND_COAGULATION_CASCADE

5

FOCAL_ADHESION [202]

43

#05

INSULIN_SIGNALING

23

ONE_CARBON_METABOLISM

5

STRIATED_MUSCLE_CONTRACTION_PATHWAY

4

IL18_SIGNALING_PATHWAY

50

#06

NUCLEAR_RECEPTORS_METAPATHWAY

32

EXTRACELLULAR_VESICLES_IN_THE_CROSSTALK_OF_CARDIAC_CELLS

4

PATHWAYS_IN_CLEAR_CELL_RENAL_CELL_CARCINOMA

5

INSULIN_SIGNALING

35

#07

NONALCOHOLIC_FATTY_LIVER_DISEASE

22

VEGFAVEGFR2_SIGNALING

11

FOCAL_ADHESION_PI3K_AKT_MTOR

8

STRIATED_MUSCLE_CONTRACTION

17

#08

ANGIOPOIETIN_LIKE_PROTEIN_8_REGULATLATORY_PATHWAY

20

MYOMETRIAL_RELAXATION_AND_CONTRACTION

7

COMPLEMENT_ACTIVATION

3

PI3K_AKT_SIGNALING_PATHWAY

50

#09

IL18_SIGNALING

29

FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT

4

PI3KAKT_SIGNALING

8

SENESCENCE_AND_AUTOPHAGY_IN_CANCER

26

#10

MAPK_SIGNALING_PATHWAY

27

NRF2_PATHWAY

6

TYROBP_CAUSAL_NETWORK

4

ANGIOPOIETIN_LIKE_PROTEIN_8_REGULATORY

28

#11

PI3KAKT_SIGNALING_PATHWAY

31

AMINO_ACID_METABOLISM

5

FOCAL_ADHESION

6

EGFEGFR_SIGNALING_PATHWAY [163]

31

#12

TYPE_I_COLLAGEN_SYNTHESIS_IN_THE_CONTEXT_OF_OSTEOGENESIS_IMPERFECTA

10

CILIARY_LANDSCAPE

7

CILIARY_LANDSCAPE

6

MAPK_SIGNALING_PATHWAY

39

#13

MYOMETRIAL_RELAXATION_AND_CONTRACTION

20

EGFEGFR_SIGNALING_PATHWAY

6

MACROPHAGE_MARKERS

2

MIRNA_TARGETS_IN_ECM_AND_MEMBRANE_RECEPTORS

16

#14

EGFEGFR_SIGNALING_PATHWAY [163]

19

INTRACELLULAR_TRAFFICKING_PROTEINS_INVOLVED_IN_CMT_NEUROPATHY

3

GLYCOGEN_SYNTHESIS_AND_DEGRADATION

3

ADIPOGENESIS

27

#15

MIRNA_TARGETS_IN_ECM_AND_MEMBRANE_RECEPTORS

10

ADIPOGENESIS

5

OXIDATIVE_DAMAGE

3

CIRCADIAN_RHYTHM_RELATED_GENES

33

#16

SENESCENCE_AND_AUTOPHAGY_IN_CANCER

15

FOCAL_ADHESION [

6

  

EBOLA_VIRUS_PATHWAY_ON_HOST

25

#17

AMPACTIVATED_PROTEIN_KINASE_AMPK

12

TYPE_I_COLLAGEN_SYNTHESIS_IN_THE_CONTEXT_OF_OSTEOGENESIS_IMPERFECTA

3

  

TGFBETA_SIGNALING_PATHWAY

25

#18

SMALL_CELL_LUNG_CANCER

14

FATTY_ACID_BETA_OXIDATION

3

  

EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER

27

#19

CALCIUM_REGULATION_IN_THE_CARDIAC_CELL

17

OXIDATIVE_STRESS

3

  

HEPATITIS_B_INFECTION

26

#20

AMINO_ACID_METABOLISM

13

STRIATED_MUSCLE_CONTRACTION

3

  

CHEMOKINE_SIGNALING_PATHWAY

27

#21

GLYCOLYSIS_AND_GLUCONEOGENESIS

9

FOCAL_ADHESION_PI3K_AKT_MTOR

7

  

APOPTOSISRELATED_NETWORK_DUE_TO_ALTERED_NOTCH3_IN_OVARIAN_CANCER

15

#22

PROLACTIN_SIGNALING

11

RENIN_ANGIOTENSIN_ALDOSTERONE_SYSTEM_RAAS

3

  

NONGENOMIC_ACTIONS_OF_125_DIHYDROXYVITAMIN_D3

17

#23

STRIATED_MUSCLE_CONTRACTION

8

ENDOPLASMIC_RETICULUM_STRESS_RESPONSE_IN_CORONAVIRUS_INFECTION

3

  

EXERCISEINDUCED_CIRCADIAN_REGULATION

14

#24

SEROTONIN_RECEPTOR_2_AND_ELKSRFGATA4

6

TRANSCRIPTIONAL_CASCADE_REGULATING_ADIPOGENESIS

2

  

RAS_SIGNALING [185]

28

#25

NRF2_PATHWAY

15

    

CALCIUM_REGULATION_IN_THE_CARDIAC_CELL

25

#26

PATHWAYS_AFFECTED_IN_ADENOID_CYSTIC_CARCINOMA

10

    

NUCLEAR_RECEPTORS_METAPATHWAY

39

#27

PPAR_SIGNALING

10

    

PATHWAYS_IN_CLEAR_CELL_RENAL_CELL_CARCINOMA

18

#28

TRANSCRIPTION_FACTOR_REGULATION_IN_ADIPOGENESIS

6

    

GLYCOGEN_SYNTHESIS_AND_DEGRADATION [40]

12

#29

MET_IN_TYPE_1_PAPILLARY_RENAL_CELL_CARCINOMA

9

    

BRAINDERIVED_NEUROTROPHIC_FACTOR_BDNF_SIGNALING_PATHWAY

23

#30

FATTY_ACID_BETA_OXIDATION

7

    

GASTRIN_SIGNALING_PATHWAY

20

#31

FRAGILE_X_SYNDROME

13

    

CILIARY_LANDSCAPE

29

#32

INSULIN_SIGNALLING_IN_HUMAN_ADIPOaCYTES_DIABETIC_CONDITION

4

    

AMPACTIVATED_PROTEIN_KINASE_AMPK

15

#33

INSULIN_SIGNALLING_IN_HUMAN_ADIPOCYTES_NORMAL_CONDITION

4

    

REGULATION_OF_ACTIN_CYTOSKELETON

23

#34

ENDOPLASMIC_RETICULUM_STRESS_RESPONSE_IN_CORONAVIRUS_INFECTION

8

    

SMALL_CELL_LUNG_CANCER

18

#35

ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY

10

    

FRAGILE_X_SYNDROME

20

#36

LEPTIN_SIGNALING_PATHWAY

10

    

NONSMALL_CELL_LUNG_CANCER

15

#37

BRAINDERIVED_NEUROTROPHIC_FACT

14

    

PATHOGENIC_ESCHERICHIA_COLI_INFECTION

13

#38

CIRCADIAN_RHYTHM_RELATED_GENES

17

    

SIGNALING_PATHWAYS_IN_GLIOBLASTOMA

16

#39

MITOCHONDRIAL_LCFATTY_ACID_BETAOXIDATION [17]

5

    

ENDOCHONDRAL_OSSIFICATION

14

#40

REGULATION_OF_ACTIN_CYTOSKELETON

14

    

ENDOCHONDRAL_OSSIFICATION_WITH_SKELETAL_DYSPLASIAS

14

#41

GASTRIN_SIGNALING_PATHWAY

12

    

CARDIAC_HYPERTROPHIC_RESPONSE

13

#42

NETRINUNC5B_SIGNALING

8

    

TYPE_I_COLLAGEN_SYNTHESIS_IN_THE_CONTEXT_OF_OSTEOGENESIS_IMPERFECTA

10

#43

G13_SIGNALING

7

    

G_PROTEIN_SIGNALING_PATHWAYS

17

#44

INTERFERON_TYPE_I_SIGNALING

8

    

THERMOGENESIS

18

#45

GENES_TARGETED_BY_MIRNAS_IN_ADIPOCYTES

5

    

TNF_RELATED_WEAK_INDUCER_OF_APOPTOSIS_TWEAK_SIGNALING_PATHWAY

11

#46

TNF_RELATED_WEAK_INDUCER_OF_APOPTOSIS_TWEAK_SIGNALING

7

    

RAC1PAK1P38MMP2_PATHWAY

14

#47

PATHWAYS_IN_CLEAR_CELL_RENAL_CELL_CARCINOMA

10

    

CELL_CYCLE

19

#48

INTEGRINMEDIATED_CELL_ADHESION

11

    

TRANSLATION_FACTORS

12

#49

ELECTRON_TRANSPORT_CHAIN_OXPHOS_SYSTEM_IN_MITOCHONDRIA

11

    

WNT_SIGNALING_PATHWAY_NETPATH

12

#50

STEROL_REGULATORY_ELEMENTBINDING_PROTEINS_SREBP

9

    

PDGFRBETA_PATHWAY

9

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