Figure 4 | Scientific Reports

Figure 4

From: Transcriptome-wide analysis reveals the coregulation of RNA-binding proteins and alternative splicing genes in the development of atherosclerosis

Figure 4

RNA-binding proteins (RBPs) regulate the alternative splicing (AS) of transcription factors (TFs), and differentially expressed target genes of transcription factors (TFs) are enriched in immune and inflammation-related pathways. (A) Venn diagram showing TFs and simultaneous deregulation of AS event (ASE) genes, p-value = 1 (B) Venn diagram showing the overlapping differentially expressed genes (DEGs) and the predicted TF (as shown in Fig. 4A) targets in the Gene Transcription Regulation Database (GTRD; http://gtrd.biouml.org/). The TFs were identified in the GTRD, p-value = 1. C The 10 most enriched GO terms as determined by overlapping target mRNAs of the TFs are shown in Fig. 4B. D The simultaneous deregulation of the AS network by the 10 most enriched RBPs (the far left part) and RASEs of TFs (the middle left part). The 10 GO terms most enriched with differentially expressed target genes of TFs (the middle right part) are shown in green.

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