Table 3 Multivariate analysis for CDCP1.

Cox proportional hazards fit
Censor: disease specific survival censor
Effect summary
Source	LogWorth		P value
pN-stage summary	2.798	+++++++	0.00159
pT-stage summary	1.64	++++	0.02293
L	0.908	++	0.12351
Resection margin	0.888	++	0.12938
Age	0.782	++	0.1653
Histology summary	0.771	++	0.16948
Gender	0.217	+	0.60618
CDCP1 low vs. high	0.148		0.71175
V	0.007		0.98386
WHO 2016 grading	–	–	–
Whole model
Number of events	95
Number of censorings	89
Total number	184

AICc	BIC
858.166	903.533

Term	Estimate	Std error	Lower 95%	Upper 95%
CDCP1 low vs. high [low]	0.043	0.117	−0.18	0.28
pT-stage summary [pT2]	−0.55	0.228	−1.02	−0.11
pT-stage summary [pT3]	0.057	0.153	−0.24	0.36
pN-stage summary [pN+]	0.047	0.178	−0.3	0.4
pN-stage summary [pN0]	−0.677	0.187	−1.04	−0.31
Gender [female]	0.063	0.122	−0.18	0.3
Age	0.013	0.01	−0.01	0.03
Resection margin [R1-R0]	0.29	0.281	−0.28	0.82
Resection margin [RX-R1]	2.301	1.098	−0.66	4.1
L[1-0]	0.433	0.283	−0.12	1
V[1-0]	0.005	0.252	−0.5	0.49
Variant summary [neuroendocrine]	1.258	0.512	0.08	2.15
Variant summary [urothelial-NOS]	−0.505	0.209	−0.91	−0.08
Variant summary [urothelial-sarcomatoid/rhabdoid]	−0.022	0.286	-0.61	0.53
Variant summary [urothelial-squamous]	−0.371	0.253	-0.87	0.12
Effect Wald tests

Source	Nparm	DF	Wald ChiSquare	Prob > ChiSq
CDCP1 low vs. high	1	1	0.14	0.712
pT-stage summary	2	2	7.49	0.024
pN-stage summary	2	2	13.24	0.001
Gender	1	1	0.27	0.604
Age	1	1	1.89	0.169
Resection margin	2	2	6.48	0.039
WHO 2016 grading	0	0	0
L	1	1	2.34	0.126
V	1	1	0	0.984
Variant summary	4	4	8.54	0.074
Risk ratios
Unit risk ratios

Per change in regressor over entire range
Term	Risk ratio	Lower 95%	Upper 95%	Reciprocal
Age	2.06	0.75	5.86	0.4863856

Risk ratios for CDCP1 low vs. high
Level1	/Level2	Risk ratio	Prob > Chisq	Lower 95%	Upper 95%
High	Low	0.92	0.712	0.58	1.45
Low	High	1.09	0.712	0.69	1.74

Risk ratios for pT-stage summary
Level1	/Level2	Risk ratio	Prob > Chisq	Lower 95%	Upper 95%
pT3	pT2	1.84	0.069	0.96	3.69
pT4	pT2	2.83	0.006	1.34	6.16
pT4	pT3	1.54	0.087	0.94	2.52
pT2	pT3	0.54	0.069	0.27	1.05
pT2	pT4	0.35	0.006	0.16	0.75
pT3	pT4	0.65	0.087	0.4	1.07

Risk ratios for pN-stage summary
Level1	/Level2	Risk ratio	Prob > Chisq	Lower 95%	Upper 95%
pN0	pN+	0.48	0.009	0.28	0.83
pNX	pN+	1.79	0.131	0.83	3.66
pNX	pN0	3.7	0.002	1.68	7.76
pN+	pN0	2.06	0.009	1.2	3.56
pN+	pNX	0.56	0.131	0.27	1.2
pN0	pNX	0.27	0.002	0.13	0.6

Risk ratios for resection margin
Level1	/Level2	Risk ratio	Prob > Chisq	Lower 95%	Upper 95%
R1	R0	1.34	0.312	0.75	2.28
RX	R0	13.34	0.074	0.7	76.53
RX	R1	9.98	0.104	0.52	60.06
R0	R1	0.75	0.312	0.44	1.33
R0	RX	0.07	0.074	0.01	1.42
R1	RX	0.1	0.104	0.02	1.93

Risk ratios for variant summary
Level1	/Level2	Risk ratio	Prob>Chisq	Lower 95%	Upper 95%
Urothelial-NOS	Neuroendocrine	0.17	0.024	0.05	0.61
Urothelial-sarcomatoid/rhabdoid	Neuroendocrine	0.28	0.1	0.07	1.1
Urothelial-sarcomatoid/rhabdoid	Urothelial-NOS	1.62	0.192	0.8	3.28
Urothelial-squamous	Neuroendocrine	0.2	0.038	0.05	0.73
Urothelial-squamous	Urothelial-NOS	1.14	0.669	0.62	2.11
Urothelial-squamous	Urothelial-sarcomatoid/rhabdoid	0.71	0.385	0.32	1.53
Urothelial-variant histology	Neuroendocrine	0.2	0.038	0.05	0.74
Urothelial-variant histology	Urothelial-NOS	1.16	0.6	0.67	1.98
Urothelial-variant histology	Urothelial-sarcomatoid/rhabdoid	0.71	0.365	0.35	1.46
Urothelial-variant histology	Urothelial-squamous	1.01	0.976	0.52	1.97
Neuroendocrine	Urothelial-NOS	5.83	0.024	1.63	20.81
Neuroendocrine	Urothelial-sarcomatoid/rhabdoid	3.6	0.1	0.91	14.27
Urothelial-NOS	Urothelial-sarcomatoid/rhabdoid	0.62	0.192	0.31	1.25
Neuroendocrine	Urothelial-squamous	5.1	0.038	1.36	19.11
Urothelial-NOS	Urothelial-squamous	0.87	0.669	0.47	1.61
Urothelial-sarcomatoid/rhabdoid	Urothelial-squamous	1.42	0.385	0.65	3.08
Neuroendocrine	Urothelial-variant histology	5.05	0.038	1.36	18.76
Urothelial-NOS	Urothelial-variant histology	0.87	0.6	0.51	1.48
Urothelial-sarcomatoid/rhabdoid	Urothelial-variant histology	1.4	0.365	0.68	2.88
Urothelial-squamous	Urothelial-variant histology	0.99	0.976	0.51	1.93

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