Table 5 Aficamten plasma concentration values at 6-, 24-, and 48-h post-dose following 0.3 and 1 mg/kg doses.

From: Effects of Aficamten on cardiac contractility in a feline translational model of hypertrophic cardiomyopathy

 

6 h

Post-dose

24 h

Post-dose

48 h

Post-dose

0.3 mg/kg (n = 8)

0.066 ± 0.006 µM

0.046 ± 0.005 µM

0.032 ± 0.003 µM

1 mg/kg (n = 8)

0.182 ± 0.024 µM

0.147 ± 0.016 µM

0.097 ± 0.014 µM

  1. Plasma values are expressed as mean ± SEM.
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