Figure 6
Lung pathology assessed by computed tomography (CT) of intratracheally formalin perfused lungs. Example of the images obtained from the lungs of an unvaccinated control and two animals vaccinated with HIMB and HIMC, respectively. (a) Larger images on the left show the tracheobronchial tree and the TB lesions. (b) The top right miniatures show the TB lesion (whitish) superimposed onto the lung volume (yellowish). (c) The bottom right miniatures show (in red) the mineralized portion of the TB lesion. (d) Volumes of lung TB lesions in each group expressed in cm3. (e) To evaluate the lesion dispersion within the lungs in each group, the number of lobes with TB lesions in each animal is plotted against the number of animals. The control group has a higher number of animals with a higher number of affected lobes than the vaccinated groups. (f) Volume of lesion mineralization expressed in cm3. (g) Ratio between the volume of mineralization and the volume of lung lesions expressed in %. Horizontal lines in (d), (f) and (g) represent the median values. Groups: Control (n = 7, green), HIMB (n = 7, blue), HIMC (n = 7, red). *P < 0.05, **P < 0.01, Kruskal–Wallis test followed by one-tailed Dunn’s test for multiple comparisons.
