Figure 4

Regional [99mTc]HMPAO SPECT perfusion measured in 5XFAD (blue) and WT (green) mice at 11.2 months of age. Standardized uptake values (SUV; left) and corresponding relative standardized uptake values with whole brain reference region (SUVRwb; right) were evaluated in the amygdala, caudate/putamen, globus pallidus, hippocampus, hypothalamus, and neocortex. No significant differences in regional perfusion were observed between 5XFAD and WT mice in any of the regions for either SUV or SUVR metrics (0.357 ≤ p ≤ 0.936). Individual subjects are represented by colored circles and the bar plot indicates mean ± SD.