Table 1 Demographic data of cohorts used for metabolic modeling: A. RISK cohort. Publicly available Risk Stratification and Identification of Immunogenetic and Microbial Markers of Rapid Disease Progression in Children with Crohn’s Disease (RISK) cohort data was accessed using GEO accession series GSE57945. RISK is a prospective inception cohort study that enrolled 1,276 pediatric patients with IBD diagnosed at 28 sites in North America between 2008 and 2012. It includes n = 163 patients with ileal Crohn's disease and n = 42 healthy controls. B. Enteroid cohort. Gene expression data for all mucosal terminal ileal biopsies used to generate enteroids included in this study have been accessed from the Sequence Read Archive (SRA) using the SRA series accession SUB7687325. *Age at diagnosis; SD: standard deviation.
A. RISK Cohort | B. Enteroid Cohort | |||
|---|---|---|---|---|
Crohn’s disease n = 163 | Controls n = 42 | Crohn’s disease n = 16 | Controls n = 12 | |
Age* (yr), mean (SD) | 11.9 (3.1) | 11.1 (3.1) | 15.8 (3.2) | 11.4 (3.5) |
Male (%) | 59% (n = 96) | 62% (n = 26) | 88% (n = 14) | 42% (n = 5) |
