Figure 7
From: In-silico study of asymmetric remodeling of tumors in response to external biochemical stimuli
Remodeling gives rise to heterogeneity in cell distribution within tumoroids. Cells alignment in cross sections of GB tumoroids with low (a) to high (c) degrees of ellipticity. More alignment zones were observed in (c) indicating the correlation between the degree of remodeling and level of cell alignment. Higher alignments were identified at the circumferential regions of tumoroids where the cells undergo larger displacement and hence tend to further align with themselves. Cells in interior regions have no alignment preference, therefore, acquire isotropic orientation. Scale bars are 200 μm.
