Figure 3
UBQLN2, but not UBQLN1, lowers α-syn levels in HEK-293 cells. (A–D) Representative immunofluorescence images show that the number of α-syn-containing cells are decreased when co-expressed with UBQLN2 (A,C; n = 10 field of cells over 3 independent experiments) but not with UBQLN1 (B,D; n = 10 field of cells over 3 independent experiments). Scale bar 100 μm (E) Expressed as a ratio of α-syn positive cells to UBQLN1 and UBQLN2, α-syn is significantly reduced in UBQLN2-expressing cells.
