Figure 2 | Scientific Reports

Figure 2

From: GTS-21, a selective alpha7 nicotinic acetylcholine receptor agonist, ameliorates diabetic nephropathy in Leprdb/db mice

Figure 2

Effects of GTS-21 on inflammatory markers (IL-6 and HMGB-1). All mice received GTS-21 (4 mg/kg, IP, B.I.D.) or vehicle for 8 weeks. The plasma and protein from kidney were collected for measuring plasma IL6 (A), plasma HMGB-1 (B), renal IL-6 (C), and renal HMGB-1 (D) using ELISA. The data is represented as mean ± SE (n = 6–7/group), *P < 0.05, **P < 0.01.

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