Figure 8
Network of the feedbacks between the variables Kact, A and App of the reduced Suwanmajo-Krishnan signaling motif. (a) In red, the three negative interactions that constitute the negative feedback loop. The blue and red interactions between A and App make up the positive feedback loop. In grey, the interactions than can be either positive or negative. (b) The two possible types of oscillator, depending on the relative strength between the feedbacks. This strength is modulated by the biochemical parameters. For example, when k3 is relatively low, the oscillations will be of the relaxation-type (bold blue for the positive feedback loop, blue time series). When k3 is high, the output will be smooth and symmetrical (bold red for the negative feedback loop, red time series).
