Table 3 Subgroup analyses according to the age and sex group and risk for all-cause dementia.
Smoking habit change | n | All-cause dementia | aIR | aHR_Model 1 | aHR_Model 2 | aHR_Model 3 | |
|---|---|---|---|---|---|---|---|
Male | Never smoker | 28,877 | 3112 | 11.91 | 1 (Ref.) | 1 (Ref.) | 1 (Ref.) |
Former smoker | 25,587 | 1941 | 11.00 | 0.910 (0.860, 0.963) | 0.937 (0.885, 0.992) | 0.927 (0.867, 0.992) | |
Smoking quitter | 12,197 | 844 | 13.45 | 1.149 (1.064, 1.240) | 1.147 (1.062, 1.238) | 1.131 (1.033, 1.238) | |
Sustained smoker | 21,848 | 1581 | 15.13 | 1.285 (1.209, 1.366) | 1.306 (1.227, 1.389) | 1.290 (1.198, 1.389) | |
New smoker | 3463 | 326 | 15.94 | 1.336 (1.192, 1.497) | 1.360 (1.213, 1.525) | 1.347 (1.195, 1.517) | |
Female | Never smoker | 102,643 | 11,450 | 15.92 | 1 (Ref.) | 1 (Ref.) | 1 (Ref.) |
Former smoker | 508 | 44 | 17.11 | 1.173 (0.872, 1.577) | 1.179 (0.877, 1.586) | 1.174 (0.873, 1.579) | |
Smoking quitter | 488 | 55 | 20.78 | 1.451 (1.113, 1.891) | 1.482 (1.137, 1.932) | 1.473 (1.129, 1.921) | |
Sustained smoker | 1624 | 168 | 20.27 | 1.423 (1.222, 1.658) | 1.415 (1.215, 1.648) | 1.406 (1.206, 1.640) | |
New smoker | 618 | 71 | 21.84 | 1.505 (1.192, 1.901) | 1.523 (1.206, 1.924) | 1.515 (1.199, 1.915) | |
P for interaction | 0.1243 | 0.1495 | 0.1324 | ||||
40–64 years | Never smoker | 59,062 | 1500 | 3.46 | 1 (Ref.) | 1 (Ref.) | 1 (Ref.) |
Former smoker | 12,859 | 214 | 2.86 | 0.827 (0.714, 0.957) | 0.843 (0.728, 0.977) | 0.843 (0.726, 0.979) | |
Smoking quitter | 8116 | 231 | 5.10 | 1.542 (1.338, 1.777) | 1.506 (1.307, 1.736) | 1.506 (1.299, 1.745) | |
Sustained smoker | 15,655 | 436 | 5.34 | 1.543 (1.382, 1.723) | 1.529 (1.368, 1.709) | 1.529 (1.361, 1.718) | |
New smoker | 2426 | 85 | 6.16 | 1.777 (1.426, 2.214) | 1.774 (1.424, 2.212) | 1.774 (1.421, 2.215) | |
≥ 65 years | Never smoker | 72,458 | 13,062 | 39.45 | 1 (Ref.) | 1 (Ref.) | 1 (Ref.) |
Former smoker | 13,236 | 1771 | 38.00 | 0.942 (0.889, 0.998) | 0.970 (0.915, 1.027) | 0.969 (0.907, 1.036) | |
Smoking quitter | 4569 | 668 | 43.55 | 1.103 (1.016, 1.198) | 1.107 (1.019, 1.203) | 1.107 (1.007, 1.217) | |
Sustained smoker | 7817 | 1313 | 50.18 | 1.271 (1.194, 1.354) | 1.292 (1.213, 1.377) | 1.292 (1.200, 1.391) | |
New smoker | 1655 | 312 | 52.36 | 1.313 (1.170, 1.472) | 1.336 (1.191, 1.498) | 1.335 (1.186, 1.504) | |
P for interaction | < 0.0001 | < 0.0001 | < 0.0001 | ||||
