Table 4 Univariable analyses of interactions between continuous TROP-2 expression and categorical clinical–pathological factors.
Variable | Category | N | Median TROP-2 expression H-score | IQR TROP-2 expression H-score | p-value |
|---|---|---|---|---|---|
AR expression (1% cutoff) | AR positive | 187 | 80.8 | (20.0–180.0) | 0.070 |
AR negative | 398 | 81.4 | (10.0–150.0) | ||
AR expression (10% cutoff) | AR positive | 146 | 102.0 | (20.0–180.0) | 0.009 |
AR negative | 439 | 55.0 | (10.0–140.0) | ||
Tumor size (TNM) | T1 | 266 | 81.0 | (15.0–155.0) | 0.598 |
T2 | 260 | 82.0 | (10.0–155.0) | ||
T3 | 40 | 87.2 | (4.5–145.0) | ||
T4 | 23 | 62.0 | (20.0–120.0) | ||
Nodal status | Node positive | 376 | 80.0 | (20.0–180.0) | 0.016 |
Node negative | 211 | 60.0 | (10.0–149.0) | ||
Nodal status (TNM) | N0 | 376 | 60.0 | (10.0–149.0) | 0.119 |
N1 | 155 | 75.0 | (20.0–180.0) | ||
N2 | 32 | 88.0 | (27.5–160.0) | ||
N3 | 24 | 95.0 | (20.0–165.0) | ||
Differentiation grade | 1 | 7 | 120.0 | (0.0–150.0) | 0.479 |
2 | 60 | 100.0 | (20.0–165.0) | ||
2 | 522 | 60.0 | (10.0–150.0) | ||
Associated DCIS | Absent | 221 | 40.0 | (7.0–125.0) | < 0.001 |
Present | 368 | 82.5 | (20.0–180.0) | ||
LVI | Absent | 359 | 70.0 | (20.0–150.0) | 0.006 |
Present | 111 | 100.0 | (30.0–200.0) | ||
Histological subtype | IBC-NST | 471 | 70.0 | (12.0–150.0) | < 0.001 |
Mixed | 11 | 70.0 | (20.0–150.0) | ||
Apocrine | 26 | 180.0 | (110.0–200.0) | ||
BCmedullary | 34 | 40.5 | (7.0–150.0) | ||
Metaplastic | 27 | 45.0 | (10.0–100.0) | ||
Other | 20 | 15.0 | (0.0–95.0) |
