Figure 6
Network topology in human dendritic cells of key pathways in A. fumigatus response. Regulatory network model showing the signaling pathways central to dendritic cell immune answer in presence of A. fumigatus under influence of platelet rich plasma (PRP). The cellular function of proteins according to pantherDB is highlighted by different overlay colors: red highlights stimuli nodes of the network, light-red inflammatory proteins, blue illustrates proteins with regulatory influence on apoptosis, while orange marks proteins connected to developmental processes. All proteins directly connected to cellular immune response regulation are colored green. All interactions are covered by two different types: inhibitory (red lines with T-shaped endpoint) and activations (green arrows).
