Table 3 Antimicrobial activity of thioxothiazolidinyl-acetamide compounds (6a–o).

From: New thioxothiazolidinyl-acetamides derivatives as potent urease inhibitors: design, synthesis, in vitro inhibition, and molecular dynamic simulation

 

Microorganism

S. aureus ATCC 25923

E. coli ATCC 25922

P. vulgaris

C. albicans ATCC 10261

Compounds

MIC* MBC*

MIC* MBC*

MIC* MBC*

MIC* MFC*

6a

 > 512 ND

 > 512 ND

 > 512 ND

 > 512 ND

6b

 > 512 ND

 > 512 ND

 > 512 ND

 > 512 ND

6c

 > 512 ND

 > 512 ND

 > 512 ND

 > 512 ND

6d

 > 512 ND

 > 512 ND

 > 512 ND

 > 512 ND

6e

 > 512 ND

 > 512 ND

 > 512 ND

 > 512 ND

6f.

 > 512 ND

 > 512 ND

 > 512 ND

 > 512 ND

6 g

 > 512 ND

 > 512 ND

 > 512 ND

 > 512 ND

6 h

 > 512 ND

 > 512 ND

 > 512 ND

 > 512 ND

6i

 > 512 ND

 > 512 ND

 > 512 ND

 > 512 ND

6 g

 > 512 ND

 > 512 ND

 > 512 ND

 > 512 ND

6 k

 > 512 ND

 > 512 ND

 > 512 ND

 > 512 ND

6 l

 > 512 ND

 > 512 ND

 > 512 ND

 > 512 ND

6 m

 > 512 ND

 > 512 ND

 > 512 ND

 > 512 ND

6n

128 > 512

 > 512 ND

 > 512 ND

 > 512 ND

6o

128 256

512 > 512

 > 512 ND

 > 512 ND

Ciprofloxacin/Fluconazole

0.5 ND

0.25 ND

1 ND

4 ND

  1. *MIC Minimum Inhibitory Concentration, MBC/MFC Minimum Bactericidal/Fungicidal, MICs and MBCs are expressed as µg/ml.
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