Figure 8

Principal component analysis of the untargeted metabolomic tests for less-polar/apolar metabolites of femora, comparing an affected group with a control group using cortical and trabecular samples from human osteoarchaeological remains in a C18 column and a nanoflow-UHPLC-Orbitrap-HRMS ESI positive mode platform. (A) Cortical bone R2(cum):0.603, Q2(cum):0.212, N = 18, 1780 variables; (B) trabecular bone R2(cum):0.71, Q2(cum):0.64. N = 18, 1623. X-Dots represent affected individuals in cortical bone. Dots represent individuals from the control group in cortical bone. X-squares represent affected individuals in trabecular bone. Squares represent individuals from the control group in trabecular bone. Ellipses indicate 95% of confidence for the PCA model. The explained variances of selected principal components are shown in brackets.