Figure 2 | Scientific Reports

Figure 2

From: Identification of TP53 mutations in circulating tumour DNA in high grade serous ovarian carcinoma using next generation sequencing technologies

Figure 2

Longitudinal patient monitoring via TP53 mutation in plasma ctDNA. (a–d) Line graph denotes the clinical status of four HGSOC patients that were longitudinally monitored throughout their disease course. ctDNA levels indicated by solid lines, different mutations indicated by changing point. CA-125 indicated by dashed line graph with upside-down triangles. Horizonal dashed line indicates the CA-125 positivity threshold of 35 units/mL of blood. Therapy time frames are indicated by coloured boxes with treatment noted in the centre. Vertical dashed lines indicate time of scans or surgery with the outcome named above the line. PD progressive disease, SD stable disease, PR partial response, CR complete response, DB debulking.

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