Table 2 Blood collections and timings.

From: Identification of TP53 mutations in circulating tumour DNA in high grade serous ovarian carcinoma using next generation sequencing technologies

Patient

Stage

1st round chemotherapy (cycles)

Length of time# (weeks)

Concordant mutations in blood vs tissue (%)

Blood tube

Time to process (HH:MM)

Volume (ml)

Nearest CA-125 level (U/ml)

OC1^

IIIa

Carboplatin/paclitaxel (1)

 − 4

1 (50%)

EDTA

3:44

5

OC2

III

Carboplatin/paclitaxel (6)

 − 14

0 (0%)

EDTA

5:11

5

OC3

IIIc

Carboplatin/paclitaxel (6)

 − 67

1 (50%)

EDTA

20:34

5

13

OC4

IIIc

Carboplatin/paclitaxel (6)

 − 142

1 (50%)

EDTA

3:12

5

142

OC5

IVa

Chemotherapy (Neoadj) (3)

 − 30

N/A (CR*)

EDTA

4:21

5

33

OC6

III

Cisplatin/paclitaxel (6)

 − 26

0 (0%)

EDTA

4:21

5

25

OC7

III

Carboplatin/paclitaxel (Neoadj) (3)

11

0 (0%)

EDTA

23:02

5

OC8

III

Cisplatin/pegylated liposomal doxorubicin (Neoadj) (4)

 − 22

0 (0%)

Streck

19:15

4.5

OC9

III

Cisplatin/gemcitabine (6)

 − 196

0 (0%)

EDTA

2:23

5

OC10

IIIc

Carboplatin/paclitaxel (6)

 − 109

1 (100%)

EDTA

23:04

5

  1. N/A not assessable.
  2. #Time between blood collection and tissue biopsy.
  3. *CR—no residual tumour tissue at interval debulking.
  4. ^Ascites noted after debulking.