Figure 1

Longitudinal change in serum HBsAg levels during the 14-year follow-up period in HBeAg-seronegative chronic hepatitis B patients. (A) Among patients with genotype B HBV infection by rs1710 genotypes (P = 0.013). (B) Among patients with genotype B HBV infection by rs2770 genotypes (P = 0.0081). (C) Among genotype C HBV infection by rs1710 genotypes (P = 0.0452). (D) Among genotype C HBV infection by rs1710 genotypes (P = 0.6977). P values were estimated by the generalized linear mixed model (GLIMMIX) with the adjustment of other significant predictors of HBsAg seroclearance in proportional hazards models.