Table 3 Multiple predictors for the seroclearance of HBsAg in HBeAg-seronegative chronic hepatitis B patients with genotype B HBV infection.

Age

 < 40

1.00 (Referent)

40–49

0.90 (0.55–1.46)

0.660

50–59

1.22 (0.77–1.93)

0.391

 ≥ 60

1.99 (1.11–3.59)

0.022

Gender

Female

1.00 (Referent)

Male

0.62 (0.41–0.94)

0.025

Cigarette smoking

No

1.00 (Referent)

1.00 (Referent)

Yes

1.34 (0.93–1.92)

0.113

1.45 (1.01–2.09)

0.046

Alcohol drinking

No

1.00 (Referent)

Yes

0.92 (0.53–1.61)

0.779

Body mass index (Kg/m²)^a

 < 30

1.00 (Referent)

 ≥ 30

2.02 (1.05–3.86)

0.034

Serum alanine aminotransferase level (U/L)

 < 45

1.00 (Referent)

 ≥ 45

1.22 (0.50–2.99)

0.665

HBV DNA level (copies/mL)

 ≥ 10,000

1.00 (Referent)

1.00 (Referent)

300–9999

1.83 (1.16–2.87)

0.009

1.13 (0.70–1.83)

0.610

Undetectable

4.54 (2.84–7.26)

 < .0001

2.64 (1.58–4.40)

0.000

HBsAg level (IU/mL)

 ≥ 1000

1.00 (Referent)

1.00 (Referent)

100–999

4.86 (2.27–10.39)

 < .0001

5.03 (2.35–10.78)

 < .0001

 < 100

17.64 (8.49–36.65)

 < .0001

15.24 (7.20–32.26)

 < .0001

rs1710

Recessive model

0.94 (0.57–1.53)

0.797

Additive model

0.86 (0.66–1.12)

0.256

0.74 (0.56–0.98)

0.035

rs2770

Recessive model

0.53 (0.26–1.09)

0.086

Additive model

0.77 (0.58–1.01)

0.062

0.69 (0.52–0.91)

0.009