Table 4 Multiple predictors for the seroclearance of HBsAg in HBeAg-seronegative chronic hepatitis B patients with genotype C HBV infection.
Baseline characteristics | Crude rate ratio (95% CI) | P valuec | Adjusted rate ratio (95% CI) | P valuec |
|---|---|---|---|---|
Age | ||||
< 40 | 1.00 (Referent) | |||
40–49 | 1.54 (0.87–2.74) | 0.142 | ||
50–59 | 1.69 (0.95–3.00) | 0.075 | ||
≥ 60 | 2.63 (1.31–5.29) | 0.007 | ||
Gender | ||||
Female | 1.00 (Referent) | |||
Male | 0.97 (0.66–1.43) | 0.878 | ||
Cigarette smoking | ||||
No | 1.00 (Referent) | |||
Yes | 1.64 (1.08–2.47) | 0.020 | ||
Alcohol drinkinga | ||||
No | 1.00 (Referent) | |||
Yes | 1.34 (0.78–2.32) | 0.293 | ||
Body mass index (Kg/m2)b | ||||
< 30 | 1.00 (Referent) | |||
≥ 30 | 1.68 (0.82–3.46) | 0.160 | ||
Serum alanine aminotransferase level (U/L) | ||||
< 45 | 1.00 (Referent) | |||
≥ 45 | 0.87 (0.41–1.88) | 0.728 | ||
HBV DNA level (copies/mL) | ||||
≥ 10,000 | 1.00 (Referent) | |||
300–9999 | 1.33 (0.82–2.16) | 0.246 | ||
Undetectable | 2.75 (1.65–4.60) | 0.000 | ||
HBsAg level (IU/mL) | ||||
≥ 1000 | 1.00 (Referent) | 1.00 (Referent) | ||
100–999 | 3.57 (2.18–5.84) | < .0001 | 3.66 (2.23–6.00) | < 0.0001 |
< 100 | 12.62 (7.79–20.42) | < .0001 | 12.84 (7.93–20.79) | < 0.0001 |
rs1710 | ||||
Recessive model | 2.12 (1.35–3.33) | 0.001 | ||
Additive model | 1.37 (1.03–1.81) | 0.029 | 1.43 (1.08–1.88) | 0.012 |
rs2770 | ||||
Recessive model | 0.82 (0.44–1.53) | 0.532 | ||
Additive model | 0.81 (0.60–1.08) | 0.154 | ||
