Figure 1 | Scientific Reports

Figure 1

From: Modelling altered signalling of G-protein coupled receptors in inflamed environment to advance drug design

Figure 1

Overview of the reaction network. Biochemical reaction network for the \(\mu\)-opioid receptor signalling pathway, connecting the receptor cycle to the G-protein cycle and further to the signal cycle of membrane calcium channel modulation, see “The reaction network” for an explanation. The focal point of this study is the analysis of the impact that the rates for ligand-induced receptor activation (blue) and for constitutive G-protein activation (orange) have onto the overall dynamics. The values of the rate constants \(k_j\) can be found in Table  2.

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