Figure 1
From: Mechanism of cystogenesis by Cd79a-driven, conditional mTOR activation in developing mouse nephrons
Cyst progression in Cd79a-Tsc1 knockout (KO) mouse kidneys. (a) Gross appearance of a cystic kidney. Sections at 4 weeks of age by hematoxylin and eosin stain. (b, c) Time-course progression of renal cysts. A series of representative images from the age of 1.5 to 17 weeks and the corresponding cystic indices are shown. The cyst index is given by a fraction of cystic lesions in whole kidney area. (d) Progressive enlargement of Cd79a-Tsc1 KO kidneys. A dramatic increase in kidney weight is observed after 4 weeks. The ratio of total kidney weight to body weight is indicated as a percentage. (e) Changes in renal function. Blood urea nitrogen (BUN, mg/dL) levels steeply rose after 12 weeks in Cd79a-Tsc1 KO mice compared with controls. (f) Kaplan–Meier analysis shows reduced viability of C79a-Tsc1 KO mice after 20 weeks of age. Control n = 15, male n = 8, female n = 7. Values represent mean ± SEM, and statistical significance was determined by two-way ANOVA. *P < 0.05, **P < 0.01, ***P < 0.001 and ****P < 0.0001.
