Figure 2
From: Mechanism of cystogenesis by Cd79a-driven, conditional mTOR activation in developing mouse nephrons
Features of cystogenesis in Cd79a-Tsc1 knockout (KO) mouse kidneys. Representative histology sections of Cd79a-Tsc1 KO kidneys are shown at postnatal day (P) 11 (a), 4 weeks (b), and 9 weeks (c). At P11, Cd79a-Tsc1 KO tubules exhibited cysts, which initially emerged in the peripheral cortex (dashed arrows) and expanded to the medulla at 4 weeks of age. The early cysts at 4 weeks were lined with epithelial cells and had an array of morphologic subtypes: low cuboidal (arrows), flattened (asterisks), and tall columnar/hypertrophic with karyocytomegaly (double arrows). In the expanding cysts at the later stage of 9 weeks, a fraction of the cells detached and exfoliated into the tubular lumens (arrowheads). An intense focal proliferation was occasionally observed (micropapillary lesion, double arrowheads). Dashed box areas are magnified.
