Table 2 Selectivity indices “SIs” for the tested compounds against avian influenza A/H5N1 and human influenza A/H1N1 virus in the MDCK cell line.
Phytochemical compound | Chemical classification | IAV subtype | CC50 (mg/ml) | IC50 (µg/ml) | Selectivity index (SI) |
|---|---|---|---|---|---|
Strychnine Sulfate | Indole Alkaloids | H5N1 | > 10 | 11.851 | > 843 |
H1N1 | 0.06 | > 1.67*105 | |||
Reserpine | H5N1 | 1.4 | 42.36 | > 33 | |
H1N1 | ND | N/A | |||
Brucine | H5N1 | > 10 | > 10,000 | N/A | |
H1N1 | ND | N/A | |||
Eserine | H5N1 | > 10 | > 10,000 | N/A | |
H1N1 | ND | N/A | |||
Ergometrine | H5N1 | 8.23 | > 1000 | N/A | |
H1N1 | ND | N/A | |||
Harmalol | β-Carboline Indole Alkaloids | H5N1 | > 10 | 0.02 | > 5*105 |
H1N1 | 0.035 | > 2.8*105 | |||
Harmane | H5N1 | 7.183 | 0.023 | > 3.12*105 | |
H1N1 | 0.033 | > 2.17*105 | |||
Harmaline | H5N1 | 0.475 | 3.42 | 138 | |
H1N1 | 0.056 | 8482 | |||
Harmine | H5N1 | > 10 | > 10,000 | N/A | |
H1N1 | ND | N/A | |||
Norharmane | H5N1 | > 10 | > 10,000 | N/A | |
H1N1 | N/A | N/A | |||
Zanamivir | NAI (drug control) | H5N1 | > 10 | 0.079 | > 1.26*105 |
H1N1 | 0.291 | > 3.4*104 | |||
Amantadine HCl | M2-channel blocker | H5N1 | 1.103 | 17.59 | 62.71 |
H1N1 | 14.86 | 74.32 |
