Table 4 The mechanism of antiviral action for the investigated indole and β-carboline indole alkaloids represented as viral inhibition (%) in a concentration-dependent manner.
Compound | Concentration (µg/ml) | Mechanism of Action | ||
---|---|---|---|---|
Viral replication (%) | Viricidal (%) | Viral adsorption (%) | ||
Harmalol | 0.1 | 87.5 | 41.5 | 60.3 |
1 | 96.9 | 50.9 | 74.5 | |
10 | 98.7 | 58 | 82.1 | |
Harmane | 10 | 83.3 | 31.8 | 43.4 |
100 | 97.5 | 41.8 | 48.7 | |
1000 | 96.7 | 82.1 | 61.4 | |
Harmaline | 1 | 28.3 | 91 | 34 |
10 | 40.3 | 96.7 | 46.2 | |
100 | 48.7 | 98.6 | 51.8 | |
Strychnine Sulfate | 1 | 19.4 | 29.4 | 90.1 |
10 | 27.3 | 37 | 99.5 | |
100 | 42 | 49.2 | 99 |