Figure 3 | Scientific Reports

Figure 3

From: Synergy of ruthenium metallo-intercalator, [Ru(dppz)2(PIP)]2+, with PARP inhibitor Olaparib in non-small cell lung cancer cells

Figure 3

Ru-PIP and Olaparib combination enhances apoptotic cell death. (a) DNA histograms showing cell cycle distributions of A549 cells treated with Ru-PIP (25 µM), Olaparib (5 µM) or both for 24 and 48 h. (b) Quantification of cell cycle phase distributions from a. (c) Annexin V-FITC assay of A549 cells treated with Ru-PIP (25 µM), Olaparib (5 µM) or both for 24 and 48 h. The scatterplots showing the percentage of cells in each quadrant. (d) Quantification of apoptotic cells from c. Mean ± SD of two independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001 by ANOVA.

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