Figure 1 | Scientific Reports

Figure 1

From: Coronary artery disease patient-derived iPSC-hepatocytes have distinct miRNA profile that may alter lipid metabolism

Figure 1

The miRNA expression profile changes during hepatocyte differentiation from iPSCs through DE to HLCs. Heatmap includes differentially expressed (FDR < 0.05) miRNAs between differentiation stages as well as miRNAs expressed only in one or two differentiation stages. Clusters 1, 2 and 3 represent miRNAs that were specific to HLCs, iPSCs and DEs, respectively. The iPSC samples from two cell lines (UTA.11916.EURCSp and UTA.12212.EURCAs) were identified as outliers and excluded from the analysis. iPSC, induced pluripotent stem cells; DE, definitive endoderm; HLC, hepatocyte-like cells; PHH, primary human hepatocyte; HepG2, liver hepatocellular carcinoma cell line.

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