Table 1 Interpretation of persistence statistics. An advantage of using persistent homology with a SEDT filtration is its interpretability. Here we list the persistent statistics that we use and their morphological interpretation. We use ‘Q.’ for quadrant, ‘p.’ for percentile, ‘st. dev.’ for the standard deviation, IQR for the interquartile range, and micro-hole radius or size refers to the radius of the largest inscribed (open) circle. The inter-micro-hole distance is half the distance from one micro-hole to the next nearest micro-hole.

From: Persistent homology analysis distinguishes pathological bone microstructure in non-linear microscopy images

\(H_*\)

Q

Persistent statistic

Interpretation

\(H_0\)

2

Number of points

Number of micro-holes

\(H_0\)

2

Mean birth

Mean micro-hole radius (of largest inscribed circle)

\(H_0\)

2

Median birth

Median micro-hole radius

\(H_0\)

2

25p. birth

Minimum radius of largest 25% of micro-holes

\(H_0\)

2

IQR birth

Range in radii of middle 50% of micro-holes

\(H_0\)

2

St. dev. birth

Spread of micro-hole radii

\(H_0\)

2

Mean death

Average micro-hole crowding (mean of inter-micro-hole distance)

\(H_0\)

2

Median death

Median inter-micro-hole distance

\(H_0\)

2

25p. death

Maximum of smallest 25% of the inter-micro-hole distances

\(H_0\)

2

IQR death

Range in the middle 50% of the inter-micro-hole distances

\(H_0\)

2

St. dev. death

Spread of inter-micro-hole distances

\(H_0\)

2

Persistent entropy

Diversity of micro-hole lifetimes

\(H_0\)

2

Number micro-holes \(r \ge 2\)

Number of micro-holes with radius greater than or equal to 2

\(H_0\)

2

Number micro-holes \(r < 2\)

Number of micro-holes with radius less than 2

\(H_1\)

1

Number of points

Number of bone regions surrounded by micro-holes

\(H_1\)

1

Mean birth

Mean distance from micro-holes at which loop is formed

\(H_1\)

1

Median birth

Middle of the distances from micro-holes at which loop is formed

\(H_1\)

1

25p. birth

Distance 25% through distances from micro-holes when loop is formed

\(H_1\)

1

IQR birth

Range of middle 50% of distances from micro-holes when loop is formed

\(H_1\)

1

St. dev. birth

Spread of distances from micro-holes at which loop is formed

\(H_1\)

1

Mean death

Mean of the radii of regions surrounded by micro-holes

\(H_1\)

1

Median death

Radius of middle-sized bone region surrounded by micro-holes

\(H_1\)

1

25p. death

Max radius of smallest 25% of bone regions surrounded by micro-holes

\(H_1\)

1

IQR death

Range in radii of middle 50% of bone regions surrounded by micro-holes

\(H_1\)

1

St. dev. death

Spread of radii of bone regions surrounded by micro-holes

\(H_1\)

1

Persistent entropy

Diversity of lifetimes for bone regions surrounded by micro-holes