Table 3 Chemomodulatory effects of P. niruri extracts and fractions on the cytotoxicity of DOX against MCF-7 and MCF-7ADR cell lines.

From: Cytotoxic and chemomodulatory effects of Phyllanthus niruri in MCF-7 and MCF-7ADR breast cancer cells

Extract or fraction

MCF-7

MCF-7ADR

(IC50 µg/mL)

R-fraction (%)

(IC50 µg/mL)

R-fraction (%)

DOX

0.2 ± 0.06

0.44 ± 0.03

9.9 ± 1.1

5.2 ± 0.04

DOX + Ext-1 (100 µg/mL)

1.2 ± 0.08*

1.7 ± 0.3

0.27 ± 0.01*

N/A

DOX + Ext-2 (100 µg/mL)

1.9 ± 0.12*

N/A

38 ± 2.3*

N/A

DOX + Fr-3 (10 µg/mL)

0.054 ± 0.001*

N/A

0.23 ± 0.01*

N/A

DOX + Fr-4 (100 µg/mL)

1.6 ± 0.13*

N/A

9.9 ± 0.82

N/A

DOX + Fr-5 (100 µg/mL)

1.2 ± 0.1*

N/A

1.9 ± 0.45*

0.73 ± 0.01

DOX + Fr-6 (100 µg/mL)

0.8 ± 0.02*

1.9 ± 0.08

3.3 ± 0.07*

N/A

  1. #N/A means not applicable. Data are presented as mean ± SD; n = 3.
  2. *Significantly different from DOX treatment.
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