Table 5 Chemomodulatory effect of subfractions (B1–B4) of Fr-3 on the cytotoxicity of DOX against MCF-7ADR cell line.

From: Cytotoxic and chemomodulatory effects of Phyllanthus niruri in MCF-7 and MCF-7ADR breast cancer cells

Subfraction

MCF-7ADR

(IC50 µg/mL)

R-fraction (%)

DOX

9.9 ± 1.1

5.2 ± 0.04

DOX + B1 (1:10)

1.5 ± 0.3*

N/A

CI index/ CI value

Synergism/0.157

DOX + B2 (1:10)

0.03 ± 0.001*

N/A

CI index/ CI value

Synergism/0.003

DOX + B3 (1:10)

0.35 ± 0.02*

N/A

CI index/ CI value

Synergism/0.038

DOX + B4 (1:10)

0.56 ± 0.04*

N/A

CI index/ CI value

Synergism/0.061

  1. #N/A means not applicable. Data are presented as mean ± SD; n = 3.
  2. *Significantly different from DOX treatment.
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