Figure 4 | Scientific Reports

Figure 4

From: Distilling functional variations for human UGT2B4 upstream region based on selection signals and implications for phenotypes of Neanderthal and Denisovan

Figure 4

Function of the segments in chr4:70389000-70392000 (a) and mutations in seg3 (b). Each bar represents one plasmid. All data is displayed as mean ± standard deviation (SD). The x axis and * represent relative luciferase activity and P < 10−6, respectively. In part a, the lines in left indicate the relative location of the three segments. “Seg” is the abbreviation for “segment”. “−1” and “−2” represent core haplotype 1 and 2, respectively. The data is normalized to the read of empty vector (pGL3-promoter). For part b, the above plasmid (seg3-1) is the original construct while the below ones are from mutagenesis. Mg and the number after @ represent mutagenesis and SNP position in chr4, respectively. The data is normalized by the result of original plasmid (seg3-1).

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