Figure 2 | Scientific Reports

Figure 2

From: The tight junction protein occludin modulates blood–brain barrier integrity and neurological function after ischemic stroke in mice

Figure 2

Immunofluorescence analysis of occludin, claudin-5, and ZO-1 24 h after cerebral infarction in wild-type mice. Images and quantification for immunofluorescence analysis were obtained from samples collected from the peri-infarct area shown in (A). Occludin (B), claudin-5 (D), and ZO-1 (F) expressions are decreased in the ischemic lesion 24 h after PIT. (C–G) show box and whiskers with maximum and minimum of the relative area of each protein to wild-type control. Claudin-5 (D and E) and ZO-1 (F and G) also decreased at 24 h after stroke compared to physiological controls. Student’s t-test is performed; *P < 0.05. Scale bar = 100 µm. n = 8 each. LEL: lycopersicon esculentum lectin, PIT; photochemically induced thrombosis.

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