Figure 5
From: CD47 antisense oligonucleotide treatment attenuates obesity and its-associated metabolic dysfunction
CD47 ASO treatment increased activity in diet-induced obese mice. Mice were housed in Sable Promethion system for indirect calorimetry analysis. (A) Food intake; (B) Oxygen consumption of three day/night cycles and regression plot of dark period oxygen consumption versus body weight (BW); (C) RER (VCO2/VO2); (D) Energy expenditure of three day/night cycles and regression plot of dark period energy expenditure versus BW; (E) Voluntary wheel running distance of three day/night cycles and regression plot of dark period wheel running distance versus BW; (F) Skeletal muscle gene expression by qPCR; (G) Skeletal muscle DNA copy number by qPCR. Data are presented as mean ± SE (n = 4 mice /group). *P < 0.05.
