Figure 3 | Scientific Reports

Figure 3

From: Inhibition of nicotinamide dinucleotide salvage pathway counters acquired and intrinsic poly(ADP-ribose) polymerase inhibitor resistance in high-grade serous ovarian cancer

Figure 3

Effect of treatment on NAD+ metabolism and apoptosis. Relative intracellular NAD+  levels after 24 h of treatment (a). Western blot (b) and densitometry (c) of cleaved caspase-3 (CC3) expression after 5 days of treatment as a measure of apoptosis. Immunofluorescent staining (d) and quantification (e) of γH2A.X foci after 24 h of treatment as a measure of DNA damage. Experiments were repeated three times. Error bars represent SEM. Statistical significance was determined using Student’s t tests. *p < 0.05, **p < 0.01, ***p < 0.001.

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